反应详情

A mixture of 2-carboxy-3-(4-fluorophenyl)-furo[3,2-b]pyridine (1.8 g, 7 mmol), copper metal (0.56 g, 8.81 mmol) in quinoline (10 ml) was heated at reflux. After 45 min., the reaction was cooled to room temperature and the product was extracted into water. The aqueous layer was acidified with hydrochloric acid and acetic acid. The product was filtered and dissolved in ether. The ether layer was dried over sodium sulfate and concentrated in vacuo. Purification by flash chromatography using ethyl acetate-hexanes (1:9) as the eluant gave 3-(4-fluorophenyl)-furo[3,2-b]pyridine as a solid (0.85 g).

1. temperaturewas heated
2. temperatureat reflux
3. extractionthe product was extracted into water
4. filtrationThe product was filtered
5. dissolutiondissolved in ether
6. dry with materialThe ether layer was dried over sodium sulfate
7. concentrationconcentrated in vacuo
8. customPurification by flash chromatography