Hydrochloric Acid → HCID 22988187, compound

Participants

Reaction Steps

To a vigorously stirred solution of the product from stage b) (5.5 g) in diethyl ether (100 ml) under nitrogen was added 2M aqueous hydrogen chloride (100 ml) and stirring continued for 36 hours. The phases were separated and the organic phase was extracted with 2M aqueous hydrogen chloride (2×20 ml). The combined aqueous phases were extracted with diethyl ether (2×20 ml) and the organic extracts discarded. The aqueous phase was evaporated in vacuo then azeotroped with toluene (3×50 ml). Trituration with diethyl ether followed by filtration and vacuum drying gave the title compound, m.p. 165-70° C.

Provenance & Evidence