HCID 21918641, compound → HCID 21918689, compound

HRID 987022Notes

Reaction equation

CC(C1C=C(CC(N2CCN(C3C=CC([N+]([O-])=O)=CC=3)CC2)=O)C=C(C(C)(C)C)C=1O)(C)C.[CH3:34][C:35]([C:38]1[CH:43]=[C:42]([C:44]([N:46]2[CH2:51][CH2:50][N:49]([C:52]3[CH:57]=[CH:56][C:55]([N+:58]([O-])=O)=[CH:54][CH:53]=3)[CH2:48][CH2:47]2)=O)[CH:41]=[C:40]([C:61]([CH3:64])([CH3:63])[CH3:62])[C:39]=1[OH:65])([CH3:37])[CH3:36]>>[CH3:37][C:35]([C:38]1[CH:43]=[C:42]([CH2:44][N:46]2[CH2:47][CH2:48][N:49]([C:52]3[CH:53]=[CH:54][C:55]([NH2:58])=[CH:56][CH:57]=3)[CH2:50][CH2:51]2)[CH:41]=[C:40]([C:61]([CH3:64])([CH3:63])[CH3:62])[C:39]=1[OH:65])([CH3:34])[CH3:36]

Participants

Reactant 2

HCID 21918641HCID 21918641, compound

HCID 21918705HCID 21918705, compound

Product 1

HCID 21918689HCID 21918689, compoundYield 75%

Procedure

The experimental protocol used is the same as that described for intermediate 9.2, with 2,6-bis-(1,1-dimethylethyl)-4-{[[4-(4-nitrophenyl)-1-piperazinyl]-carbonyl]-methyl}-phenol replacing the 2,6-bis-(1,1-dimethylethyl)-4-{[4-(4-nitrophenyl)-1-piperazinyl]-carbonyl}-phenol. A pale pink powder is obtained with a yield of 75%. Melting point: 152-154° C.

Workup

customA pale pink powder is obtained with a yield of 75%

Sources & evidence

ORD record: ord-f3ed14f683864fbeb5f8f439ed098c31
Source dataset: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06630461B2

Reaction notes

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