HCID 15389740, compound → HCID 178488077, compound

HRID 987024Notes

Reaction equation

HRID 987024 reaction equation
Cl.CC(C1C=[C:8](C=C(C(C)(C)C)C=1O)[C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19]([C:21]2[S:22][CH:23]=[CH:24][CH:25]=2)=[NH:20])=[CH:14][CH:13]=1)=O)(C)C.[CH3:34][O:35][C:36]1[CH:37]=[C:38]2[C:42](=[CH:43][CH:44]=1)[NH:41][CH:40]=[C:39]2[CH2:45][C:46]([N:48]1CCN(C2C=CC(N)=CC=2)[CH2:50][CH2:49]1)=[O:47].CC(C1C=C(C=C(C(C)(C)C)C=1O)C(NC1C=CC(N)=CC=1)=O)(C)C>>[CH3:34][O:35][C:36]1[CH:37]=[C:38]2[C:42](=[CH:43][CH:44]=1)[NH:41][CH:40]=[C:39]2[CH2:45][C:46]([N:48]1[CH2:8][CH2:9][N:11]([C:12]2[CH:13]=[CH:14][C:15]([NH:18][C:19]([C:21]3[S:22][CH:23]=[CH:24][CH:25]=3)=[NH:20])=[CH:16][CH:17]=2)[CH2:50][CH2:49]1)=[O:47]

Participants

4

Reactant 3

HCID 15389740HCID 15389740, compoundHCID 22987726HCID 22987726, compoundHCID 178441077HCID 178441077, compound

Product 1

HCID 178488077HCID 178488077, compoundYield 20%

Procedure

The experimental protocol used is the same as that described for the compound 1, with 1-[(5 methoxy-1H-indole-3-yl)methylcarbonyl]-4-(4-aminophenyl)-piperazine replacing the 3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-(4-aminophenyl)-benzamide. The expected product is isolated in the form of the free base with a yield of 20% (pale yellow powder). Melting point: 221-222° C.

Sources & evidence

ORD record
ord-a2aefddbbab74fb58ec846de02e6e160
Source dataset
uspto-grants-2003_10
Patent number
US06630461B2

Reaction notes

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