HCID 86600355, compound → HCID 86600356, compound

HRID 987031Notes

Reaction equation

HRID 987031 reaction equation
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([C:16](=[CH2:30])[C:17]([NH:19][C:20]2[CH:25]=[C:24]([N+:26]([O-])=O)[CH:23]=[CH:22][C:21]=2[OH:29])=[O:18])[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:4])[CH3:3].CC(C1C=C(C(=C)C(NC2C=CC(O)=C([N+]([O-])=O)C=2)=O)C=C(C(C)(C)C)C=1O)(C)C>>[CH3:4][C:2]([C:5]1[CH:6]=[C:7]([C:16](=[CH2:30])[C:17]([NH:19][C:20]2[CH:25]=[C:24]([NH2:26])[CH:23]=[CH:22][C:21]=2[OH:29])=[O:18])[CH:8]=[C:9]([C:12]([CH3:13])([CH3:14])[CH3:15])[C:10]=1[OH:11])([CH3:1])[CH3:3]

Participants

3

Reactant 2

HCID 86600355HCID 86600355, compoundHCID 86600357HCID 86600357, compound

Product 1

HCID 86600356HCID 86600356, compoundYield 74%

Procedure

The experimental protocol used is the same as that described for intermediate 18.2, with 3-[(3,5-bis-(1,1-dimethylethyl)-4-hydroxyphenyl]-N-(2-hydroxy-5-nitrophenyl)-2-propenamide replacing the 3-[(3,5-bis-(1,1-dimethylethyl)-4-hydroxyphenyl]-N-(4-hydroxy-3-nitrophenyl)-2-propenamide. A yellow powder is obtained with a yield of 74%. The product is used without additional purification in the following stage.

Workup

  1. customA yellow powder is obtained with a yield of 74%
  2. customThe product is used without additional purification in the following stage

Sources & evidence

ORD record
ord-a80fedd494c5429180e42becbfa83f1e
Source dataset
uspto-grants-2003_10
Patent number
US06630461B2

Reaction notes

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