反应详情

To a stirred solution of 200 mg (0.32 mmol) 2-methyl-butyric acid 8-[6-benzylcarbamoyl-5-(tert.-butyl-dimethyl-silanyloxy)-3-oxo-hexyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester in 5 ml methylene chloride are added 0.3 g (2.6 mmol) trifluoroacetic acid. After 2 hours at room temperature the reaction mixture is quenched with saturated aqeous sodium bicarbonate. The aqueous phase is separated and extracted twice with ethyl acetate. The combined organic phases are dried over sodium sulfate and the solvent is evaporated. The residue is chromatographed over silica gel (hexane/ethyl acetate 7/3 to 2/3) affording the title compound as a white powder foam. MS (FAB) m/z 480 ([M+Li]+)

1. customAfter 2 hours at room temperature the reaction mixture is quenched with saturated aqeous sodium bicarbonate
2. customThe aqueous phase is separated
3. extractionextracted twice with ethyl acetate
4. dry with materialThe combined organic phases are dried over sodium sulfate
5. customthe solvent is evaporated
6. customThe residue is chromatographed over silica gel (hexane/ethyl acetate 7/3 to 2/3)