Hantzsch ester → 2-Cyano-3-{4-[2-(4-methylsulfonyloxyphenyl)ethoxy]phenyl}propanol

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Reaction Steps

Ethyl 2-cyano-3-{4-[2 (4-methylsulfonyloxypbenyl)ethoxy]phenyl } propanoate A mixture of compound (a) (1.69 g; 4.07 mmole) and diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate (2.06 g; 8.14 mmole) was slowly heated to more than 190° C. under vacuum and thereafter allowed to cool to room temperature. The crude product was purified by chromatography on silica gel using heptane:ethyl acetate (gradient 2:1 to 1:1) as eluant to give 1.55 g (yield 91%) of the desired product.

Provenance & Evidence