Hydrochloric Acid → HCID 12138346, compound

Participants

Reaction Steps

To sodium dihydrobis(2-methoxyethoxy)aluminate (70% in toluene, 22.7 g, 0.078 mol), was added dropwise a solution of methyl 3,5-bis(3,5-dimethylthiobenzyloxy)benzoate (21.0 g) in tetrahydrofuran (180 ml) in a stream of nitrogen at 5-10° C. during 30 minutes. After completion of the addition, the mixture was stirred for 5 hours and then poured into 2L of diluted hydrochloric acid, followed by extraction with 1L of chloroform. The extract was evaporated to dryness, and the residue was purified by means of chromatography using chloroform as the developing solvent, giving 3,5-bis(3,5-dimethylthiobenzyloxy)benzyl alcohol. The yield was 17.5 g (85.6%).

Provenance & Evidence