HCID 9874017, compound → HCID 9894984, compound

Participants

Reaction Steps

Following the procedure described in step E for the preparation of compound I, 38 mg (0.059 mmol) of (S)-2-benzenesulfonylamino-3-{[7-(3-tert-butoxycarbonylaminopropoxy)-4-oxo-4H-quinolizine-3-carbonyl]-amino}-propionic acid tert-butyl ester afforded after flash chromatography (ethanol to ethanol:ammonium hydroxide:water (8:1:1) and treatment with trifluoroacetic acid, 12 mg (36% yield) of pure desired product which was characterized with 1HNMR (400 MHz, D2O) δ: 2.25-2.29 (m, 2H), 3.26-3.31 (t, J=6.5 Hz, 1H), 3.42-3.50 (dd, J=10.0 and 13.5 Hz, 1H), 3.84-3.90 (dd, J=14.5 and 4.0 Hz, 1H), 4.23-4.26 (m, 3H), 6.90-6.94 (m, 2H), 7.04-7.10 (m, 2H), 7.56 (d, J=9.5 Hz, 1H), 7.64 (d, J=7.5 Hz, 2H), 7.69-7.75 (m, 1H), 7.91 (d, J=8.5 Hz, 1H).

Provenance & Evidence