Trifluoroacetic acid → HCID 56626233, compound

Participants

Reaction Steps

To a solution of (S)-2-Benzenesulfonylamino-3-{3-[7-(3-benzyloxycarbonylamino-propoxy)-4-oxo-4H-quinolizin-3-yl]-ureido}-propionic acid tert-butyl ester (25 mg, 0.036 mmol) in dichloromethane (3 mL) was added TFA(3 ml) at room temperature. The reaction mixture was stirred overnight and then solvents were evaporated under reduced pressure. The residue was triturated with ether(2×5 ml) and dried. The resulting solid was purified by flash chromatography (10% methanol in ethyl acetate) to give 18 mg of compound VI which was characterized by 1HNMR (300 MHz) (CD3OD) δ: 8.56 (d, 1H, J=7 Hz), 8.40 (s, 1H), 7.92 (m, 2H), 7.42-7.60 (m, 4H), 7.25 (m, 5H), 6.91-7.04 (m, 2H), 5.12 (s, 2H), 4.19 (t, 2H), 3.63 (m, 1H), 3.50 (m, 2H), 3.20 (m, 2H), 2.02 (m, 2H)

Provenance & Evidence