Triethylamine → HCID 56611972, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of (S)-3-{[7-(3-amino-propoxy)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-2-benzenesulfonylamino-propionic acid tert-butyl ester (10.0 mg, 0.015 mmol) in anhydrous acetonitrile (0.5 ml) were added triethylamine (4 μl, 0.030 mmol) and methyl isocyanate (1 μl, 0.015 mmol). The mixture was stirred for 5 minutes at 0° C. and 30 minutes at room temperature, quenched with water and extracted with dichloromethane (3x). The combined organic layers were dried (MgSC4) and concentrated to give 4.1 mg (81% yield) of desired product.

Provenance & Evidence