HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4,6-Trimethylpyridine → HCID 56605553, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4,6-Trimethylpyridine | HCID 7953 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | (S)-3-amino-2-benzenesulfonylamino-propionic acid tert-butyl ester hydrochloride | HCID 22853534 | — |
| Reactant | HCID 22988038 | HCID 22988038 | — |
| Product | HCID 56605553 | HCID 56605553 | 90.9% |
Reaction Steps
To a mixture of 4-oxo-7-[3-(pyrimidin-2-ylamino)-propoxy]-4H-quinolizine-2-carboxylic acid (6.9 mg, 0.020 mmol), was added HATU (9.9 mg, 0.026 mmol), (S)-3-amino-2-benzenesulfonylamino-propionic acid tert-butyl ester hydrochloride (8.1 mg, 0.024 mmol) and collidine (19 μl, 0.140 mmol). The mixture was stirred for 45 minutes, concentrated and flash chromatographed (0-5% methanol in dichiloromethane) to give 10.3 mg (82% yield) of desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06630488B1 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-0a933d8671b44343ba6b349bac695f97 |
| Source note | uspto-grants-2003_10 |