Trifluoroacetic acid → HCID 86759200, compound

Participants

Reaction Steps

To a solution of (S)-2-Benzenesulfonylamino-3-{[7-(tert-butoxycarbonylamino-methyl)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-propionic acid tert-butyl ester (21.2 mg, 0.035 mmol) in dichloromethane (2 mL) was added trifluoroacetic acid (2 mL). The mixture was stirred overnight, evaporated to dryness and triturated in ether (3×) and dichloromethane (1×). The solid was dried and characterized to yield 62% (10 mg, 0.022 mmol) of the title compound which was characterized by 1HNMR (400 MHz, CD3OD) δ: 9.03 (s, 1H), 7.93-7.83 (m, 3H), 7.64 (dd, 1H, J=9, 1.5 Hz), 7.55-7.45 (m, 3H), 7.26 (s, 1H), 6.92 (d, 1H, J=1.5 Hz), 4.29 (s, 2H), 4.22 (dd, 1H, J=7.5, 5 Hz), 3.81-3.77 (dd, 1H, J=13.5, 5 Hz), 3.55-3.45 (m, 1H).

Provenance & Evidence