Trifluoroacetic acid → HCID 86759201, compound

Participants

Reaction Steps

Using the procedure described for the preparation of compound XXX (step E), (S)-2-benzenesulfonylamino-3-{[8-(4-tert-butoxycarbonylamino-butoxy)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-propionic acid tert-butyl ester (38 mg, 0.058 mmol) was treated with trifluoroacetic acid in dichloromethane to afford compound XXXII (32 mg, 90%) as a yellow solid which was characterized by 1HNMR (400 MHz, CD3OD) δ: 9.06 (1H, d, J=8.0 Hz), 7.86 (2H, dd, J=1.2, 7.7 Hz), 7.46-7.54 (3H, m), 7.23 (1H, d, J=2.5 Hz), 7.07 (1H, d, J=1.2 Hz), 7.03 (1H, dd, J=2.7, 8.0 Hz), 6.59 (1H, d, J=1.6 Hz), 4.27 (2H, t, J=5.7 Hz), 4.22 (1H, dd, J=5.1, 8.6 Hz), 3.79 (1H, dd, J=5.0, 13.4 Hz), 3.51 (1H, dd, J=8.6, 13.5 Hz), 3.06 (2H, t, J=7.4 Hz), 1.88-2.01 (4H, 2 multiplets).

Provenance & Evidence