Trifluoroacetic acid → HCID 86759203, compound

Participants

Reaction Steps

Using the procedure described for the preparation of compound XXX (step E), (S)-2-benzenesulfonylamino-3-{[8-(5-tert-butoxycarbonylamino-pentyloxy)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-propionic acid tert-butyl ester (42 mg, 0.063 mmol) was treated with trifluoroacetic acid in dichloromethane to afford compound XXXIV (34 mg, 86%) as a yellow solid which was characterized by 1HNMR (400 MHz, CD3OD) δ: 9.04 (1H, d, J=7.9 Hz), 7.86 (2H, dd, J=1.2, 7.7 Hz), 7.46-7.54 (3H, m), 7.21 (1H, d, J=2.5 Hz), 7.06 (1H, d, J=1.1 Hz), 7.02 (1H, dd, J=2.7, 8.0 Hz), 6.58 (1H, d, J=1.6 Hz), 4.21-4.25 (3H, m), 3.79 (1H,dd, J=5.0, 13.5 Hz), 3.52 (1H, dd, J=8.5, 13.4 Hz), 2.99 (2H, t, J=7.4 Hz), 1.92-1.99, 1.74-1.82, 1.61-1.68 (6H, 3 multiplets).

Provenance & Evidence