4-Methylmorpholine → HCID 9821989, compound

Participants

Reaction Steps

To a stirring mixture of 8-Chloro-4-oxo-4H-quinolizine-3-carboxylic acid (22 mg, 0.098 mmol) in anhydrous DMF (1.5 ml) at room temperature was sequentially added (+/−)-3-amino-3-phenyl-propionic acid ethyl ester hydrochloride (28.4 mg, 0.123 mmol), N-methylmorpholine (32.4 μl, 0.295 mmol) and O-(7-azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (48.6 mg, 0.128 mmol). The resulting mixture was allowed to stir at room temperature for 2 h. The solvent was removed under vacuum and the resulting residue was subjected to a silica gel chromatography (Rex:EtOAc=1:1 to pure EtOAc) to give desired product as yellowish solid (32 mg, 81%).

Provenance & Evidence