Trifluoroacetic acid → HCID 9821989, compound

Participants

Reaction Steps

To a stirred solution of (+/−)-3-{[8-(2-tert-butoxycarbonylamino-ethylamino)-4-oxo-4H-quinolizine-3-carbonyl]-amino}-3-phenyl-propionic acid (20.5 mg, 0.042 mmol) in dichloromethane (1 ml) at room temperature was added trifluoroacetic acid (1 ml). The resulting mixture was stirred at room temperature for 45 min. The solvent was removed under vacuum and the resulting residue was subjected to a silica gel chromatography (EtOH:H2O: NH4OH, 90:5:5) to give desired product which was further lyophilized to afford a yellowish solid (30 mg, 73%) which was characterized by 1HNMR (400 MHz, D2O) δ: 2.58-2.65 (m, 2H), 2.90-3.10 (m, 2H), 3.15-3.25 (m, 2H), 5.21 (m, 1H), 6.0-8.7 (m, 10H).

Provenance & Evidence