4-Nitrobenzenesulfonyl chloride → 2-Ethoxy-3-(4-{2-[4-(4-nitrobenzenesulfonyloxy)phenyl]-ethoxy}phenyl)propanoic acid ethyl ester

HRID 987254Notes

Reaction equation

HRID 987254 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[CH:5]([O:23][CH2:24][CH3:25])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[CH:9][CH:8]=1)[CH3:2].[N+:27]([C:30]1[CH:35]=[CH:34][C:33]([S:36](Cl)(=[O:38])=[O:37])=[CH:32][CH:31]=1)([O-:29])=[O:28]>>[CH2:1]([O:3][C:4](=[O:26])[CH:5]([O:23][CH2:24][CH3:25])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[CH:17]=[CH:18][C:19]([O:22][S:36]([C:33]3[CH:32]=[CH:31][C:30]([N+:27]([O-:29])=[O:28])=[CH:35][CH:34]=3)(=[O:37])=[O:38])=[CH:20][CH:21]=2)=[CH:9][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 54239207HCID 54239207, compound

Product 1

HCID 865950612-Ethoxy-3-(4-{2-[4-(4-nitrobenzenesulfonyloxy)phenyl]-ethoxy}phenyl)propanoic acid ethyl ester

Procedure

2-Ethoxy-3-{4-[2-(4-hydroxyphenyl)ethoxy]phenyl}propanoic acid ethyl ester (described in Example 26b) was esterified with 4-nitrobenzenesulfonyl chloride using the same method as in Example 26 (c) to give 2-ethoxy-3-(4-{2-[4-(4-nitrobenzenesulfonyloxy)phenyl]-ethoxy}phenyl)propanoic acid ethyl ester.

Sources & evidence

ORD record
ord-4d6ffd6dc9234dc8a9e76980703757e5
Source dataset
uspto-grants-2003_10
Patent number
US06630600B1

Reaction notes

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