2-(4-Methylsulfonyloxyphenyl)ethylmethanesulfonate → HCID 53731141, compound

HRID 987258Notes

Reaction equation

HRID 987258 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH:5]([O:15][CH2:16][CH3:17])[CH:6]([C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)[CH3:7])[CH3:2].[CH3:19][S:20]([O:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31]CS([O-])(=O)=O)=[CH:26][CH:25]=1)(=[O:22])=[O:21]>>[CH2:1]([O:3][C:4](=[O:18])[CH:5]([O:15][CH2:16][CH3:17])[CH:6]([C:8]1[CH:9]=[CH:10][C:11]([O:14][CH2:31][CH2:30][C:27]2[CH:26]=[CH:25][C:24]([O:23][S:20]([CH3:19])(=[O:21])=[O:22])=[CH:29][CH:28]=2)=[CH:12][CH:13]=1)[CH3:7])[CH3:2]

Participants

3

Reactant 2

HCID 227084532-(4-Methylsulfonyloxyphenyl)ethylmethanesulfonateHCID 54190417HCID 54190417, compound

Product 1

HCID 53731141HCID 53731141, compound

Procedure

3-(4-Hydroxyphenyl)-2-ethoxybutanoic acid ethyl ester was alkylated with 2-(4-methanesulfonyloxyphenyl)ethylmethanesulfonate (described in Example 1a) using the same method as in Example 1(b) to give 2-ethoxy-3-{4-[2-(4-methanesulfonyloxyphenyl)ethoxy]-phenyl}butanoic acid ethyl ester as a diastereomeric mixture.

Sources & evidence

ORD record
ord-9b0c1f819d2b40058f057aecb3572be2
Source dataset
uspto-grants-2003_10
Patent number
US06630600B1

Reaction notes

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