HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | (S)-3-(4-(Benzyloxy)phenyl)-2-ethoxypropanoic acid | HCID 11044786 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate | HCID 9816147 | 76% |
Reaction Steps
3-(4-Benzyloxyphenyl)-2-(S)-ethoxypropanoic acid (7.13 g; 21.7 mmole) was hydrogenated at atmospheric pressure for 2 hours in ethyl acetate (70 ml) using Pd/C as catalyst. Purification by chromatography on silica gel using toluene:ethyl acetate as eluant gave 3.83 g (yield in 3 step 76%) of (S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06630600B1 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-caf95dd5ee3346559c3d50f01f669c98 |
| Source note | uspto-grants-2003_10 |