HCID 69629020, compound → HCID 17922561, compound

HRID 987300Notes

Reaction equation

HRID 987300 reaction equation
C([O:8][C:9](=[O:31])/[C:10](/[O:26][CH2:27][CH2:28][O:29][CH3:30])=[CH:11]/[C:12]1[CH:17]=[CH:16][C:15]([O:18]CC2C=CC=CC=2)=[CH:14][CH:13]=1)C1C=CC=CC=1>CO.[Pd]>[OH:18][C:15]1[CH:16]=[CH:17][C:12]([CH2:11][CH:10]([O:26][CH2:27][CH2:28][O:29][CH3:30])[C:9]([OH:31])=[O:8])=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 69629020HCID 69629020, compound

Product 1

HCID 17922561HCID 17922561, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

(Z)-3-[4-(Benzyloxy)phenyl]-2-(2-methoxyethoxy)-2-propenoic acid benzyl ester (1.75 g; 4.2 mmole) was hydrogenated in methanol (50 ml) at atmospheric pressure using Pd/C (5%) as catalyst. The mixture was filtered through celite and evaporated in vacuo to give 3-(4-hydroxyphenyl)-2-(2-methoxyethoxy)propanoic acid 0.83 g (88% yield).

Workup

  1. filtrationThe mixture was filtered through celite
  2. customevaporated in vacuo

Sources & evidence

ORD record
ord-35ae085e74d84a4ea1ea3a2977d1cbe3
Source dataset
uspto-grants-2003_10
Patent number
US06630600B1

Reaction notes

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