4-(2-Hydroxyethyl)benzonitrile → HCID 54431091, compound

HRID 987335Notes

Reaction equation

HRID 987335 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH:5]([S:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[CH3:2].[C:22]([C:24]1[CH:32]=[CH:31][C:27]([CH2:28][CH2:29]O)=[CH:26][CH:25]=1)#[N:23]>>[CH2:1]([O:3][C:4](=[O:21])[CH:5]([S:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:29][CH2:28][C:27]2[CH:31]=[CH:32][C:24]([C:22]#[N:23])=[CH:25][CH:26]=2)=[CH:9][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 28008154-(2-Hydroxyethyl)benzonitrileHCID 57320974HCID 57320974, compound

Product 1

HCID 54431091HCID 54431091, compound

Procedure

3-(4-Hydroxyphenyl)-2-phenylsulfanylpropanoic acid ethyl ester was reacted with p-cyanophenethyl alcohol using the same method as in Example 38(c) to give 3-{4-[2-(4-cyanophenyl)ethoxy]phenyl}-2-phenylsulfanylpropionic acid ethyl ester.

Sources & evidence

ORD record
ord-77f24850957b44c587902cd7b946f93e
Source dataset
uspto-grants-2003_10
Patent number
US06630600B1

Reaction notes

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