3-(4-Hydroxyphenyl)-2-isopropoxypropanoic acid methyl ester → 2-Isopropoxy-3-[4-(2-{4-methylsulfonyloxyphenyl}ethoxy)phenyl]propanoic acid methyl ester

HRID 987339Notes

Reaction equation

HRID 987339 reaction equation
[CH3:1][O:2][C:3](=[O:17])[CH:4]([O:13][CH:14]([CH3:16])[CH3:15])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.[CH3:18][S:19]([O:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][CH2:30]CS([O-])(=O)=O)=[CH:25][CH:24]=1)(=[O:21])=[O:20]>>[CH3:1][O:2][C:3](=[O:17])[CH:4]([O:13][CH:14]([CH3:15])[CH3:16])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:30][CH2:29][C:26]2[CH:25]=[CH:24][C:23]([O:22][S:19]([CH3:18])(=[O:20])=[O:21])=[CH:28][CH:27]=2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 149239963-(4-Hydroxyphenyl)-2-isopropoxypropanoic acid methyl esterHCID 227084532-(4-Methylsulfonyloxyphenyl)ethylmethanesulfonate

Product 1

HCID 572273272-Isopropoxy-3-[4-(2-{4-methylsulfonyloxyphenyl}ethoxy)phenyl]propanoic acid methyl ester

Procedure

2-Isopropoxy-3-[4-(2-{4-methylsulfonyloxyphenyl}ethoxy)phenyl]propanoic acid methyl ester was synthesized from 3-(4-hydroxyphenyl)-2-isopropoxypropanoic acid methyl ester and 2-(4-methanesulfonyloxyphenyl)ethylmethanesulfonate (described in Example 1b) using the same method as in Example 58e.

Sources & evidence

ORD record
ord-58203a6aee034f198882b2561347ad39
Source dataset
uspto-grants-2003_10
Patent number
US06630600B1

Reaction notes

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