O-Cresol → 4-Nonyl-o-cresol

Participants

Reaction Steps

o-Cresol (108 g, 1 mol), tripropylene (131.74 g), and Amberlyst 15 (8.55 g) were stirred for 20 h at 75° C. and 2 h at 90° C. At ambient temperature the reaction mixture was mixed with heptanes and filtered to remove the catalyst. Removal of the solvent in vacuo gave crude product (225.23 g), which was distilled to obtain pure 4-nonyl-2-cresol (203.76 g) in 87% yield.

Provenance & Evidence