反应详情

3-Methyl-5-nonylsalicylaldehyde (1b) (570.8 g, 2.18 mol) was treated with hydroxylamine sulfate (197 g, 1.2 mol) and anhydrous sodium acetate (197 g, 2.40 mol) in methanol (1.5 L) at reflux for 16.5 h. Crude product in the solvent was filtered and concentrated to obtain 3-methyl-5-nonylsalicylaldoxime (595.45 g) in 98.6% yield.

1. temperatureat reflux for 16.5 h
2. filtrationCrude product in the solvent was filtered
3. concentrationconcentrated