Acetic Anhydride → HCID 18008627, compound

Participants

Reaction Steps

4-Nonyl-2-cresol (1a) (934 g, 3.99 mol) was treated with acetic anhydride (456.6 g, 4.42 mol) in the presence of a few drops of concentrated sulfuric acid at 110° C. for 1 h. After cooling to ambient temperature, the reaction mixture was transferred into a 4-I separatory funnel with aid of heptane (400 mL). The resulting organic phase was washed with aqueous sodium bicarbonate solution and water until the pH became 6 or so. The heptane phase was dried over sodium sulfate and concentrated to obtain 4-nonyl-2-methylphenyl acetate (1098.3 g) in 99.7% yield.

Provenance & Evidence