Acetic Anhydride → HCID 18008627, compound

Participants

Reaction Steps

4-Octyl-2-cresol (6a) (245.51 g, 1.116 mol) was treated with acetic anhydride (149.3 g, 1.45 mol) in the presence of a few drops of concentrated sulfuric acid at 110° C. for 1.5 h. After cooling to ambient temperature, the reaction mixture was transferred into a 4-I separatory funnel with aid of heptane (400 mL). The resulting organic phase was washed with aqueous sodium bicarbonate solution and water until the pH became 6 or so. The heptane phase was dried over sodium sulfate and concentrated to obtain 4-nonyl-2-methylphenyl acetate (285.5 g) in 97.6% yield.

Provenance & Evidence