Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-BOC-ethylenediamine | HCID 187201 | — |
| Reactant | 5-Bromo-2-chloropyrimidine | HCID 606665 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 59771109 | HCID 59771109 | 85.4% |
Reaction Steps
A mixture of 5-bromo-2-chloropyrimidine (500 mg), N-Boc-ethylenediamine (496 mg), and triethylamine (1 mL) in ethanol (10 mL) was heated at 80° C. for 4 hours. The reaction was then concentrated in vacuo and the residue purified by preparative HPLC (hexanes:EtOAc; 60:40) to afford compound 10 (700 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06632809B2 |
|---|
| Source dataset | uspto-grants-2003_10 |
|---|
| ORD ID | ord-c643af08928649d885f1a53a2eebc957 |
|---|
| Source note | uspto-grants-2003_10 |
|---|
