Hexahydro-1,4-diazepine → N,N'-bis(5,6,7-trimethoxyindole-2-carbonyl)homopiperazine

HRID 987438Notes

Reaction equation

HRID 987438 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([OH:18])=O)=[CH:6]2.[NH:19]1[CH2:25][CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[NH:8][C:7]([C:16]([N:19]1[CH2:25][CH2:24][CH2:23][N:22]([C:16]([C:7]3[NH:8][C:9]4[C:5]([CH:6]=3)=[CH:4][C:3]([O:2][CH3:1])=[C:11]([O:12][CH3:13])[C:10]=4[O:14][CH3:15])=[O:18])[CH2:21][CH2:20]1)=[O:18])=[CH:6]2

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 8210525,6,7-Trimethoxy-1H-indole-2-carboxylic acid

Product 1

HCID 21891614N,N'-bis(5,6,7-trimethoxyindole-2-carbonyl)homopiperazine

Procedure

5,6,7-Trimethoxyindole-2-carboxylic acid (300 mg) and homopiperazine (60 mg) were reacted in the same manner as in Preparation Example 37 to obtain the title compound.

Sources & evidence

ORD record
ord-986b2e7a4e874d789745ea39aa45aead
Source dataset
uspto-grants-2003_10
Patent number
US06632810B2

Reaction notes

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