Water → HCID 9906201, compound

Participants

Reaction Steps

To a solution of ethyl 7-amino-6-chloro-3,4-dihydro-3-oxoquinoxaline-2-carboxylate (500mg, 1.87 mmol) in acetic acid (10 ml) was added dropwise 2,5-dimethoxytetrahydrofuran-3-aldehyde (318 μl, 2.24 mmol) at 50° C., and the mixture was stirred for 40 minutes at the same temperature. The reaction mixture was poured into water (100 ml), which was extracted with ethyl acetate. After dried over anhydrous sodium sulfate, solvent was distilled off. The residue obtained was submitted to silica gel column chromatography [ethyl acetate-hexane=3:2] to obtain 166 mg of title compound as yellowish brown oily product. Yield 26%.

Provenance & Evidence