Sodium Acetate → HCID 18008898, compound

Participants

Reaction Steps

To a suspension of ethyl 7-amino-6-methyl-3-oxo-1,2,3,4-tetrahydroquinoxaline-2-carboxylate hydrochloride (1.00 g, 3.50 mmol) and sodium acetate (345 mg, 4.20 mmol) in ethanol (35 ml) was added dropwise 2,5-dimethoxytetrahydrofuran-3-aldehyde (596 μl, 4.20 mmol), and the mixture was refluxed for 3 hours. After cooling, the residue obtained by distilling off solvent was submitted to silica gel column chromatography [ethyl acetate-hexane=3:2] to obtain 508 mg of title compound as yellowish white powder. Yield 44%.

Provenance & Evidence