Water → HCID 9807247, compound

Participants

Reaction Steps

To a solution of the compound of Example 5 (61.2 mg, 159 μmol) in N,N-dimethylformamide (1.6 ml) were added triethylamine (33.3 μl, 239 μmol) and successively ethyl 4-isocyanatobenzoate (36.5 mg, 191 μmol) at room temperature, and the mixture was stirred for 3 hours at the same temperature. Water was added to the reaction mixture and the precipitated crystals were collected by filtration. After washed with water and then with ethyl acetate, these were air-dried, thereby obtaining 27.0 mg of title compound as yellowish brown powder. Yield 32%.

Provenance & Evidence