Potassium Hydroxide → HCID 9913102, compound

HRID 987483Notes

Reaction equation

HRID 987483 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N:12]1[CH:16]=[CH:15][C:14]([CH2:17][NH:18][C:19]([NH:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([O:30]CC)=[O:29])=[CH:24][CH:23]=3)=[O:20])=[CH:13]1)[N:8]=[C:7]([C:33]([O:35]CC)=[O:34])[C:6](=[O:38])[NH:5]2.[OH-].[K+]>C(O)C>[C:28]([C:25]1[CH:24]=[CH:23][C:22]([NH:21][C:19]([NH:18][CH2:17][C:14]2[CH:15]=[CH:16][N:12]([C:11]3[CH:10]=[C:9]4[C:4]([NH:5][C:6](=[O:38])[C:7]([C:33]([OH:35])=[O:34])=[N:8]4)=[CH:3][C:2]=3[Cl:1])[CH:13]=2)=[O:20])=[CH:27][CH:26]=1)([OH:30])=[O:29]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 9807247HCID 9807247, compound

Product 1

HCID 9913102HCID 9913102, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the compound (25.4 mg, 47.2 μmol) of Example 6 in ethanol (2 ml) was added 1 mol/L aqueous solution of potassium hydroxide (189 μl, 189 μmol), and the mixture was refluxed for 1.5 hours. After cooling, solvent was distilled off. The residue was dissolved into a small quantity of water, which was brought to pH2 using 4 mol/L hydrochloric acid.

Workup

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. temperatureAfter cooling
  3. distillationsolvent was distilled off
  4. dissolutionThe residue was dissolved into a small quantity of water, which

Sources & evidence

ORD record
ord-440a4454416c4071bbf0fad0c0ae4078
Source dataset
uspto-grants-2003_10
Patent number
US06632813B1

Reaction notes

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