4-Chlorophenyl Isocyanate → HCID 18008917, compound

HRID 987485Notes

Reaction equation

HRID 987485 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:8]=[CH:7][N:6]([C:9]2[CH:18]=[C:17]3[C:12]([NH:13][C:14](=[O:24])[CH:15]([C:19]([O:21]CC)=[O:20])[NH:16]3)=[CH:11][C:10]=2[Cl:25])[CH:5]=1.[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([N:33]=[C:34]=[O:35])=[CH:29][CH:28]=1>>[Cl:25][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][C:9]=1[N:6]1[CH:7]=[CH:8][C:4]([CH2:3][NH:2][C:34]([NH:33][C:30]3[CH:31]=[CH:32][C:27]([Cl:26])=[CH:28][CH:29]=3)=[O:35])=[CH:5]1)[N:16]=[C:15]([C:19]([OH:21])=[O:20])[C:14](=[O:24])[NH:13]2

Participants

3

Reactant 2

HCID 76934-Chlorophenyl IsocyanateHCID 18008893HCID 18008893, compound

Product 1

HCID 18008917HCID 18008917, compoundYield 18.2%

Procedure

Using the compound (200 mg, 519 μmol) of Example 5 and 4-chlorophenyl isocyanate (80.6 μl, 622 μmol) and through the process similar to Example 38, 44.6 mg of title compound were obtained as yellowish brown powder. Yield 18%.

Sources & evidence

ORD record
ord-5357b49174af42519fc2002bba79b955
Source dataset
uspto-grants-2003_10
Patent number
US06632813B1

Reaction notes

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