Ethyl Acetate → HCID 18009120, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the methanesulfonate from Step I (17.3 mmol) in 20 mL of DMF was added 2-methylimidazole (4.25 g, 51.8 mmol) and potassium carbonate (7.15 g, 51.8 mmol). The reaction was heated to 100° C. for 3 hours, then cooled to room temperature. The solution was poured into EtOAc, washed with water and brine, dried (Na2SO4), filtered, and concentrated in vacuo. Purification by silica gel chromatography (3-6% MeOH/CH2Cl2) provided the titled compound.

Provenance & Evidence