Dimethyl Sulfoxide → HCID 18009118, compound

Participants

Reaction Steps

To a solution of oxalyl chloride (0.114 mL, 1.305 mmol) in 3.0 mL of dichloromethane at −78° C. was added DMSO (0.185 mL, 2.60 mmol) dropwise. After 10 minutes, a solution of the alcohol from Step K (238 mg, 0.870 mmol) in 2 mL of dichloromethane was added dropwise, followed by triethylamine (0.424 mL, 3.04 mmol). The reaction was allowed to warm to room temperature over 30 minutes. The solution was poured into 80% EtOAc/hexane, washed with sat. aq. NaHCO3, water and brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide the titled compound as a yellow oil which was used without further purification in the next reaction.

Provenance & Evidence