反应详情

A solution of 5,7-Dibromo-4-methoxy-6-azaindole 36 (680 mg, 2.22 mmol), 5% Pd/C (350 mg, 0.17 mmol) and hydrazine (2.5 mL, 80 mmol) in EtOH was heated at reflux for 1 h. The reaction mixture was allowed to cool to rt, filtered through celite and the filtrate concentrated. Aqueous NH4OH (11% in H2O, 45 mL) was added to the residue and the solution was extracted with CH2Cl2 (3×30 mL). The combined organics were dried (MgSO4), filtered and concentrated to yield 4-methoxy-6-azaindole 37 (290 mg, 1.95 mmol, 88%) as an orange solid.

1. temperatureat reflux for 1 h
2. filtrationfiltered through celite
3. concentrationthe filtrate concentrated
4. additionAqueous NH4OH (11% in H2O, 45 mL) was added to the residue
5. extractionthe solution was extracted with CH2Cl2 (3×30 mL)
6. dry with materialThe combined organics were dried (MgSO4)
7. filtrationfiltered
8. concentrationconcentrated