Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-Chloro-6-[N-(3-bromoallyl)-2-chloro-5-methylanilino]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,3-Dibromopropene | HCID 5201028 | — |
| 반응물 | 4-Chloro-6-(2-chloro-5-methylanilino)pyrimidine | HCID 18009138 | — |
| 반응물 | Isohexane ethyl acetate | HCID 21882781 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 4-Chloro-6-[N-(3-bromoallyl)-2-chloro-5-methylanilino]pyrimidine | HCID 73415729 | — |
반응 단계
4-Chloro-6-(2-chloro-5-methylanilino)pyrimidine (Reference Example 12) (0.5 g, 1.97 mmol) and 1,3-dibromopropene [cis/trans mixture] (0.6 g, 3.0 mmol) were dissolved in NMP (2 ml). Anhydrous potassium carbonate (0.54 g, 4 mmol) was added and the mixture stirred at room temperature for seventeen hours. After aqueous work-up the product was obtained by column chromatography on silica gel using EtOAc/isohexane mixtures (0.68 g, 93%). M/z 372 (MH)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06632820B1 |
| 출처 데이터셋 | uspto-grants-2003_10 |
| ORD ID | ord-24a8e50c3f764c74a097464810f01362 |
| 출처 메모 | uspto-grants-2003_10 |