1-Phenylpiperazine → HCID 9874288, compound

Participants

Reaction Conditions

Reaction Steps

2.63 g (5.1 mmol) of N-[5-chloro-2,4-bis-(piperidine-1-sulfonyl)-phenyl]-N-ethyl-N′,N′-dimethylethane-1,2-diamine, prepared as described below, are dissolved in 12 ml of 4-phenylpiperazine, and the reaction mixture is stirred at 90° C. for 9 hours. Workup entails extraction with ethyl acetate/water, drying of the combined organic phases over sodium sulfate, and removing the extractant under reduced pressure in a rotary evaporator. This is followed by purification by chromatography on silica gel (40-63μ, Merck Darmstadt; mobile phase=dichloromethane/methanol=20/1).

Provenance & Evidence