HCID 18009445, compound → HCID 18009513, compound

Participants

Reaction Steps

A mixture of 1-phenyl-1-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)-4-methylidenecyclohexane (Example 165, 38 mg, 0.11 mmol) and Pd/C (10%, 16.7 mg) in 15 mL of EtOAc was shaken under 50 psi of H2 for 2.5 h. The mixture was filtered through a plug of celite, concentrated and the residue was purified by HPLC (Waters RCM, μ Porosil, 25 mm×10 cm) using a mixture of (5:4:1 hexane-methyl tert-butyl ether-acetonitrile:hexane, 2.0/8.9 mL/min) to afford the two isomers of the title compound.

Provenance & Evidence