Methyl diethylphosphonoacetate → HCID 68831233, compound

Participants

Reaction Steps

To a solution of methyl diethylphosphonoacetate (0.088 mL, 0.48 mmol) in 2 mL of THF was added lithium bis(trimethylsilyl)amide (0.48 mL, 1N, 0.48 mmol in THF) at 0° C. and the reaction mixture stirred for 50 min The solution was then added to a solution of 4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexanone (67.1 mg, 0.20 mmol) in 2 mL of THF at −78° C. and the solution was allowed to warm to rt overnight. The solution was then filtered through a plug of silica gel, concentrated and was purified by flash chromatography (silica, EtOAc/Hexane, 3:7) to give the title compound.

Provenance & Evidence