Pyridine → HCID 18009485, compound

Participants

Reaction Steps

To a solution of 1-hydroxy-1-acetoxymethyl)-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)-cyclohexane (Example 171, isomer #1, 19.5 mg, 0.047 mmol) in 2 mL of pyridine was added SOCl2 (0.2 mL, 2.7 mmol) at 0° C. and the mixture was stirred at rt for 1 h. It was then poured into NaHCO3, extracted with CH2Cl2 (2×), dried over MgSO4 filtered and concentrated. The residue was purified by HPLC (Waters RCM, μ Porosil, 25 mm×10 cm) using a mixture of (5:4:1 hexane-methyl tert-butyl ether-acetonitrile:hexane, 7.75/6.0 mL/min) to give the title compound. 1H NMR (CDCl3) δ 8.18 (d, 1H, J=7.8 Hz), 7.60 (bs, 1H), 7.26-7.41 (m, 6H), 7.03 (t, 1H, J=7.6 Hz), 6.83 (d, 1H, J=8.3 Hz), 5.81 (s, 1H), 4.39-4.45 (m, 2H), 3.80 (d of d, 1H, J=6.4, 13.2 Hz), 3.75 (d of d, 1H, J=6.4, 13.2 Hz), 3.15 (s, 3H), 2.61 (d, 1H, J=17.7 Hz), 2.38 (d, 1H, J=17.7), 2.04 (s, 3H), 1.77-2.16 (m, 4H); Mass Spectrum (CI) m/e 394 (M+1).

Provenance & Evidence