Diethyl Ether → HCID 86759211, compound

Participants

Reaction Steps

A solution of 4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)-cyclohex-1-ene (Example 192, 146.3 mg, 0.46 mmol) and mCPBA (156.8 mg, 0.92 mmol) in 8.0 mL of CH2Cl2 was stirred at rt for 18 h. The reaction mixture was poured into ether, washed with NaHCO3 (3×), dried over Na2SO4, filtered through a plug of silica gel and concentrated The residue was purified by HPLC (Waters RCM, μ Porosil, 25 mm×10 cm) using a mixture of (5:4:1 hexane-methyl tert-butyl ether-acetonitrile:hexane, 1.0/8.0 mL/min) to give the separated cis and trans isomers.

Provenance & Evidence