Ethanolamine → HCID 178429348, compound

Participants

Reaction Conditions

Reaction Steps

Step 1) Ethyl cyanoacetate (56.5 parts) was added dropwise over 0.25 hours to a stirred solution of ethanolamine (76.25 parts) in water (18 parts) while maintaining the temperature at less than 30° C. Ethyl acetoacetate (65 parts) was then added while maintaining the temperature at less than 30° C. The mixture was stirred at 90° C. for 20 hours, cooled and poured into water (500 parts), the product isolated by filtration, washed with water and dried to give 3-cyano-6-hydroxy4-methyl-1-(2-hydroxyethyl)pyrid-2-one (45 parts).

Provenance & Evidence