(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → 4-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-3-one

Participants

Role	Name	HCID	Charge
Reactant	(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid	HCID 12135350	—
Reactant	4-Amino-1-(pyrid-3-yl)-1,2,3,4-tetrahydroisoquinoline-3-one	HCID 22312772	—
Product	4-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-3-one	HCID 10117314	—

Reaction Steps

Following General Procedure D above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 4-amino-2-phenethyl-1,2,3,4-tetrahydroisoquinoline-3-one (General Procedure 5-D), the title compound was prepared as a solid having a melting point of 75-76° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06632811B2
Source dataset	uspto-grants-2003_10
ORD ID	ord-1f8febf61a124e958647b5375ff9c95a
Source note	uspto-grants-2003_10