HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → 4-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-1-(pyrid4-yl)-1,2,3,4-tetrahydroisoquinolin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Reactant | 4-Amino-1-(pyrid-4-yl)-1,2,3,4-tetrahydroisoquinolin-3-one | HCID 22312750 | — |
| Product | 4-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-1-(pyrid4-yl)-1,2,3,4-tetrahydroisoquinolin-3-one | HCID 10205078 | — |
Reaction Steps
Following General Procedure D above using ?N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 4-amino-1-(pyrid-4-yl)-1,2,3,4-tetrahydroisoquinoline-3-one (Example 5-B), the title compound was prepared as a solid having a melting point of 100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06632811B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-943bd9b64abb47829b12b93f6ad37285 |
| Source note | uspto-grants-2003_10 |