HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxindole → HCID 86584969, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxindole | HCID 321710 | — |
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Reactant | 3-Amino-1-methyl-1,3-dihydro-2H-indol-2-one--hydrogen chloride (1/1) | HCID 22312299 | — |
| Product | HCID 86584969 | HCID 86584969 | — |
Reaction Steps
Following General Procedure I above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 3-amino-1-methyl-2-indolinone monohydrochloride (Example 5-J), the title compound, as a ˜1:1 diastereomeric mixture at C3 of the indolinone, was prepared as a white solid having a decomposition point of 215-220° C. Purification was by flash chromatography eluting with 3:1 CH2Cl2/EtOAc gradient to straight EtOAc followed by recrystalization from CHCl3. Rf=0.16 and 0.22 (EtOAc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06632811B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-3cccb0f10bc949e8abedafd87544a151 |
| Source note | uspto-grants-2003_10 |