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Isobutyl iodide → 2,4-Dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isobutyl iodide | HCID 10556 | — |
| 反応物 | 1H-1,5-Benzodiazepine-2,4(3H,5H)-dione | HCID 283534 | — |
| 生成物 | 2,4-Dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine | HCID 22312768 | — |
反応手順
2,4-Dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine was prepared following General Procedure 8-M using the product from Example 8-P, Step A and 1-iodo-2-methylpropane (Aldrich). Purification was by flash chromatography eluting with EtOAc/hexanes (3:7 gradient to 1:1), then recrystalization from EtOAc/hexanes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06632811B2 |
| 出典データセット | uspto-grants-2003_10 |
| ORD ID | ord-9d717035c08a408783fc87934743c545 |
| 出典メモ | uspto-grants-2003_10 |