HCID 22312692, compound → HCID 86584980, compound

HRID 987723Notes

Reaction equation

HRID 987723 reaction equation
[CH:1]1([CH:6]([OH:10])[C:7]([OH:9])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[NH2:12][C@H:13]([C:15]([C:17]1([NH2:42])[C:23](=[O:24])[N:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:21]2[CH:31]=[CH:32][CH:33]=[CH:34][C:20]=2[N:19]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:18]1=[O:41])=[O:16])[CH3:14]>>[CH:1]1([CH:6]([OH:10])[C:7]([NH:12][C@H:13]([C:15]([C:17]2([NH2:42])[C:23](=[O:24])[N:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:21]3[CH:31]=[CH:32][CH:33]=[CH:34][C:20]=3[N:19]([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[C:18]2=[O:41])=[O:16])[CH3:14])=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 22312692HCID 22312692, compoundHCID 69037142HCID 69037142, compound

Product 1

HCID 86584980HCID 86584980, compound

Procedure

Following General Procedure I above using cyclopentyl-α-hydroxyacetic acid (Example P) and 3-(L-alaninyl)-amino-2,4-dioxo-1,5-bis-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine hydrochloride (Example 8-W), the title compound was prepared as a white solid (melting point=139-149° C.). Purification was by flash chromatography eluting with CH2Cl2/EtOAc (1:2). Rf=0.50 and 0.39 (CH2Cl2/EtOAc, 1:2).

Workup

  1. customPurification
  2. washeluting with CH2Cl2/EtOAc (1:2)

Sources & evidence

ORD record
ord-b0a881c892e1406086b33d3a221b74db
Source dataset
uspto-grants-2003_10
Patent number
US06632811B2

Reaction notes

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