3-(Trifluoromethyl)benzeneacetic acid → 2-[(3-trifluoromethylphenyl)acetamido]butyric Acid Iso-butyl Ester

HRID 987804Notes

Reaction equation

HRID 987804 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([CH2:9][C:10]([OH:12])=O)[CH:6]=[CH:7][CH:8]=1.[NH2:15][CH:16]([CH2:24][CH3:25])[C:17]([O:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[O:18]>>[CH2:20]([O:19][C:17](=[O:18])[CH:16]([NH:15][C:10](=[O:12])[CH2:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:14])[F:13])[CH:4]=1)[CH2:24][CH3:25])[CH:21]([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 676953-(Trifluoromethyl)benzeneacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 154817722-[(3-trifluoromethylphenyl)acetamido]butyric Acid Iso-butyl Ester

Procedure

Following General Procedure BI above and using 3-trifluoromethylphenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-bc8b7e5489bf4b23aba7228a4724369b
Source dataset
uspto-grants-2003_10
Patent number
US06632811B2

Reaction notes

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